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Blood group phenotypes

Submitted by admin on Tue, 2010-04-13 17:10

Alloantibodies causing haemolytic transfusion reactions or haemolytic disease in the fetus and newborn are dependent on the frequency with which alloantigens and alloantibodies occur.
 

Major Blood Group Phenotypes and their Frequencies(1–3)

001 ABO [ABO]

Phenotype % Frequency
A1 29.7
A2 9.3
B 11.4
O 46.1
A1B 2.3
A2B 1.2

002 MNS [MNS]

Phenotype % Frequency
MMSS 6
MMss 9.1
MMSs 14.4
MNSS 3
MNss 23.3
MNSs 22.7
NNSS 0.4
NNss 15.6
NNSs 5.5

003 P [P]

Phenotype % Frequency
P1+ 74.8
P1– 25.2

004 Rh [RH]

Phenotype % Frequency
See Rh phenotypes  

005 Lutheran [LU]

Phenotype % Frequency
Lu(a+b–) 0.2
Lu(a–b+) 92.3
Lu(a+b+) 7.5
Lu(a–b–) Rare

006 Kell [KEL]

Phenotype % Frequency
K– k+ 90.9
K+ k– 0.4
K+ k+ 8.7
Kp(a+b–) <0.1
Kp(a–b+) 97.8
Kp(a+b+) 2.2

007 Lewis [LE]

Phenotype % Frequency
Le(a+b–) 22.4
Le(a–b+) 72.3
Le(a–b–) 5.3

008 Duffy [FY]

Phenotype % Frequency
Fy(a+b–) 19.7
Fy(a–b+) 32.7
Fy(a+b+) 47.6
Fy(a–b–) very rare

009 Kidd [JK]

Phenotype % Frequency
Jk(a+b–) 26.3
Jk(a–b+) 23.6
Jk(a+b+) 50.1
Jk(a–b–) rare

010 Diego [DI]**

Phenotype % Frequency
Di(a+b–) <0.01
Di(a-b+) >99.9
Di(a+b+) <0.1
Wr(a+) <0.01
Wr(b+) High incidence

011 Yt [YT]**

Phenotype % Frequency
Yt(a+b–) 91.9
Yt(a–b+) 0.3
Yt(a+b+) 7.8

012 Xg [XG]**

Phenotype % Frequency
Xg(a+) Male-65.6
  Female-88.7
Xg(a–) Male-34.4
  Female-11.3

013 Scianna [SC]**

Phenotype % Frequency
Sc:1,–2 99
Sc:–1,2 Rare
Sc:1,2 1
Sc:1,–2,Rd+ Rare
Sc:1,2,Rd+ Rare

014 Dombrock [DO]**

Phenotype % Frequency
Do(a+b–) 18
Do(a–b+) 33
Do(a+b+) 49
Gy(a–) Rare

015 Colton

Phenotype % Frequency
Co(a+b–) 90
Co(a–b+) 0.5
Co(a+b+) 9.5

016 Landsteiner-Wiener [LW]**

Phenotype % Frequency
LW(a+b–) 97
LW(a–b+) Rare
LW(a+b+) 3

017 Chido/Rogers [CH/RG]**

Phenotype % Frequency
Chido phenotype  
CH/RG: 1,2,3 88.2
CH/RG: 1,–2,3 4.9
CH/RG: 1,2,–3 3.1
CH/RG: –1,–2,–3 3.8
CH/RG: –1,2,-3 Rare
CH/RG: 1,–2,–3 Rare
Rodgers phenotype  
CH/RG: 11,12 95
CH/RG: 11,–12 3
CH/RG: –11,–12 2

018 H [H]

Phenotype % Frequency
H High incidence

019 Kx [XK]

Phenotype % Frequency
Kx High incidence

020 Gerbich [GE]**

Phenotype % Frequency
Ge:2,3,4 >99.9
Ge:–2,3,4 (Yus type) Rare
Ge:–2,–3,4 (Gerbich type) Rare
Ge:–2,–3,–4 (Leach) Rare

021 Cromer [CROM]

Phenotype % Frequency
Cra, Tca, Dra, Esa High Incidence
Tcb, Tcc, WESa Low incidence

022 Knops [KN]**

Phenotype % Frequency
Kn(a+b–) 94.5
Kn(a–b+) 1
Kn(a+b+) 4.5
McC(a+) 98
Sl(a+) 98
Yk(a+) 92

023 Indian [IN]**

Phenotype % Frequency
In(a+b–) Rare
In(a–b+) 99.9
In(a+b+) <0.1

024 Ok [OK]**

Phenotype % Frequency
Ok(a+) 100
Ok(a–) Rare

025 Raph [RAPH]

Phenotype % Frequency
MER2 92

026 John Milton Hagen [JMH]

Phenotype % Frequency
JMH High incidence

027 I [I]

Phenotype % Frequency
I High incidence

028 Globoside [GLOB]

Phenotype % Frequency
P High incidence

029 Gill [GIL]

Phenotype % Frequency
GIL High incidence

030 Rh-associated Glycoprotein [RHAG]**

Phenotype % Frequency
Duclos High incidence

031 Forssman [FORS]**

Phenotype % Frequency
FORS1 Low incidence

032 Junior [JR]**

Phenotype % Frequency
Jra High incidence

033 Langereis [LAN]**

Phenotype % Frequency
Lan High incidence

034 VEL**

Phenotype % Frequency
Vel High incidence

035 CD59**

Phenotype % Frequency
CD59.1 High incidence

036 AUG

Phenotype % Frequency
AUG1  
AUG2 >99%

Antigen Collections (series 200)**

Phenotype % Frequency
Csa 95
Csb 34
Era  >99
Erb <1
Er3 >99
Lec 1
Led 6
i  
LKE 98
Hu  
M1  
Tm  
Can  
Sext  
Sj  

Low incidence antigens (700 series)**

Phenotype % Frequency
By, Chra, Bi, Bxa, Pta, Rea, Jea , Lia, RASM, JFV, Kg, JONES, HJK, HOFM, REIT <1

High incidence antigens (901 series)**

Phenotype % Frequency
Ata, AnWj, Sda >90
Emm, PEL, ABTI, MAM  

Note: Unless indicated, frequencies are based on blood group statistics of Australian blood donors; ** Frequency is based on most populations, however variations do exist for some phenotypes in certain cultural groups. Refer to references 1 and 3 for specific references.

 

References
  1. Fung MK, Eder AF, Spitalnik SL & Westhoff CM, 2017, AABB Technical Manual 19th Edition.

  2. International Society of Blood Transfusion (ISBT). Red cell immonogenetics and blood group terminology. [cited 2020 June 26 ]. Available from: http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-blood-group-terminology.

  3. 3. Reid ME, Lomas-Francis C, Olsson ML,2012, The Blood Group Antigen Facts Book 3rd Edition.

Updated on 14 January, 2021