Alloantibodies causing haemolytic transfusion reactions or haemolytic disease in the fetus and newborn are dependent on the frequency with which alloantigens and alloantibodies occur.
Major Blood Group Phenotypes and their Frequencies(1–3)
| Phenotype | % Frequency |
|---|---|
| A1 | 29.7 |
| A2 | 9.3 |
| B | 11.4 |
| O | 46.1 |
| A1B | 2.3 |
| A2B | 1.2 |
| Phenotype | % Frequency |
|---|---|
| MMSS | 6 |
| MMss | 9.1 |
| MMSs | 14.4 |
| MNSS | 3 |
| MNss | 23.3 |
| MNSs | 22.7 |
| NNSS | 0.4 |
| NNss | 15.6 |
| NNSs | 5.5 |
| Phenotype | % Frequency |
|---|---|
| P1+ | 74.8 |
| P1– | 25.2 |
| Phenotype | % Frequency |
|---|---|
| See Rh phenotypes |
| Phenotype | % Frequency |
|---|---|
| Lu(a+b–) | 0.2 |
| Lu(a–b+) | 92.3 |
| Lu(a+b+) | 7.5 |
| Lu(a–b–) | Rare |
| Phenotype | % Frequency |
|---|---|
| K– k+ | 90.9 |
| K+ k– | 0.4 |
| K+ k+ | 8.7 |
| Kp(a+b–) | <0.1 |
| Kp(a–b+) | 97.8 |
| Kp(a+b+) | 2.2 |
| Phenotype | % Frequency |
|---|---|
| Le(a+b–) | 22.4 |
| Le(a–b+) | 72.3 |
| Le(a–b–) | 5.3 |
| Phenotype | % Frequency |
|---|---|
| Fy(a+b–) | 19.7 |
| Fy(a–b+) | 32.7 |
| Fy(a+b+) | 47.6 |
| Fy(a–b–) | very rare |
| Phenotype | % Frequency |
|---|---|
| Jk(a+b–) | 26.3 |
| Jk(a–b+) | 23.6 |
| Jk(a+b+) | 50.1 |
| Jk(a–b–) | rare |
| Phenotype | % Frequency |
|---|---|
| Di(a+b–) | <0.01 |
| Di(a-b+) | >99.9 |
| Di(a+b+) | <0.1 |
| Wr(a+) | <0.01 |
| Wr(b+) | High incidence |
| Phenotype | % Frequency |
|---|---|
| Yt(a+b–) | 91.9 |
| Yt(a–b+) | 0.3 |
| Yt(a+b+) | 7.8 |
| Phenotype | % Frequency |
|---|---|
| Xg(a+) | Male-65.6 |
| Female-88.7 | |
| Xg(a–) | Male-34.4 |
| Female-11.3 |
| Phenotype | % Frequency |
|---|---|
| Sc:1,–2 | 99 |
| Sc:–1,2 | Rare |
| Sc:1,2 | 1 |
| Sc:1,–2,Rd+ | Rare |
| Sc:1,2,Rd+ | Rare |
| Phenotype | % Frequency |
|---|---|
| Do(a+b–) | 18 |
| Do(a–b+) | 33 |
| Do(a+b+) | 49 |
| Gy(a–) | Rare |
| Phenotype | % Frequency |
|---|---|
| Co(a+b–) | 90 |
| Co(a–b+) | 0.5 |
| Co(a+b+) | 9.5 |
| Phenotype | % Frequency |
|---|---|
| LW(a+b–) | 97 |
| LW(a–b+) | Rare |
| LW(a+b+) | 3 |
| Phenotype | % Frequency |
|---|---|
| Chido phenotype | |
| CH/RG: 1,2,3 | 88.2 |
| CH/RG: 1,–2,3 | 4.9 |
| CH/RG: 1,2,–3 | 3.1 |
| CH/RG: –1,–2,–3 | 3.8 |
| CH/RG: –1,2,-3 | Rare |
| CH/RG: 1,–2,–3 | Rare |
| Rodgers phenotype | |
| CH/RG: 11,12 | 95 |
| CH/RG: 11,–12 | 3 |
| CH/RG: –11,–12 | 2 |
| Phenotype | % Frequency |
|---|---|
| H | High incidence |
| Phenotype | % Frequency |
|---|---|
| Kx | High incidence |
| Phenotype | % Frequency |
|---|---|
| Ge:2,3,4 | >99.9 |
| Ge:–2,3,4 (Yus type) | Rare |
| Ge:–2,–3,4 (Gerbich type) | Rare |
| Ge:–2,–3,–4 (Leach) | Rare |
| Phenotype | % Frequency |
|---|---|
| Cra, Tca, Dra, Esa | High Incidence |
| Tcb, Tcc, WESa | Low incidence |
| Phenotype | % Frequency |
|---|---|
| Kn(a+b–) | 94.5 |
| Kn(a–b+) | 1 |
| Kn(a+b+) | 4.5 |
| McC(a+) | 98 |
| Sl(a+) | 98 |
| Yk(a+) | 92 |
| Phenotype | % Frequency |
|---|---|
| In(a+b–) | Rare |
| In(a–b+) | 99.9 |
| In(a+b+) | <0.1 |
| Phenotype | % Frequency |
|---|---|
| Ok(a+) | 100 |
| Ok(a–) | Rare |
| Phenotype | % Frequency |
|---|---|
| MER2 | 92 |
| Phenotype | % Frequency |
|---|---|
| JMH | High incidence |
| Phenotype | % Frequency |
|---|---|
| I | High incidence |
| Phenotype | % Frequency |
|---|---|
| P | High incidence |
| Phenotype | % Frequency |
|---|---|
| GIL | High incidence |
| Phenotype | % Frequency |
|---|---|
| Duclos | High incidence |
| Phenotype | % Frequency |
|---|---|
| FORS1 | Low incidence |
| Phenotype | % Frequency |
|---|---|
| Jra | High incidence |
| Phenotype | % Frequency |
|---|---|
| Lan | High incidence |
| Phenotype | % Frequency |
|---|---|
| Vel | High incidence |
| Phenotype | % Frequency |
|---|---|
| CD59.1 | High incidence |
| Phenotype | % Frequency |
|---|---|
| AUG1 | |
| AUG2 | >99% |
| Phenotype | % Frequency |
|---|---|
| Csa | 95 |
| Csb | 34 |
| Era | >99 |
| Erb | <1 |
| Er3 | >99 |
| Lec | 1 |
| Led | 6 |
| i | |
| LKE | 98 |
| Hu | |
| M1 | |
| Tm | |
| Can | |
| Sext | |
| Sj |
| Phenotype | % Frequency |
|---|---|
| By, Chra, Bi, Bxa, Pta, Rea, Jea , Lia, RASM, JFV, Kg, JONES, HJK, HOFM, REIT | <1 |
| Phenotype | % Frequency |
|---|---|
| Ata, AnWj, Sda | >90 |
| Emm, PEL, ABTI, MAM |
Note: Unless indicated, frequencies are based on blood group statistics of Australian blood donors; ** Frequency is based on most populations, however variations do exist for some phenotypes in certain cultural groups. Refer to references 1 and 3 for specific references.
References
- Fung MK, Eder AF, Spitalnik SL & Westhoff CM, 2017, AABB Technical Manual 19th Edition.
-
International Society of Blood Transfusion (ISBT). Red cell immonogenetics and blood group terminology. [cited 2020 June 26 ]. Available from: http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-blood-group-terminology.
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3. Reid ME, Lomas-Francis C, Olsson ML,2012, The Blood Group Antigen Facts Book 3rd Edition.