Alloantibodies causing haemolytic transfusion reactions or haemolytic disease in the fetus and newborn are dependent on the frequency with which alloantigens and alloantibodies occur.
Major Blood Group Phenotypes and their Frequencies(1–5)
| Phenotype | % Frequency |
|---|---|
| A1 | 29.7 |
| A2 | 9.3 |
| B | 11.4 |
| O | 46.1 |
| A1B | 2.3 |
| A2B | 1.2 |
| Phenotype | % Frequency |
|---|---|
| MMSS | 6 |
| MMss | 9.1 |
| MMSs | 14.4 |
| MNSS | 3 |
| MNss | 23.3 |
| MNSs | 22.7 |
| NNSS | 0.4 |
| NNss | 15.6 |
| NNSs | 5.5 |
| Phenotype | % Frequency |
|---|---|
| P1+ | 74.8 |
| P1– | 25.2 |
| Phenotype | % Frequency |
|---|---|
| See Rhesus phenotypes |
| Phenotype | % Frequency |
|---|---|
| Lu(a+b–) | 0.2 |
| Lu(a–b+) | 92.3 |
| Lu(a+b+) | 7.5 |
| Lu(a–b–) | Rare |
| Phenotype | % Frequency |
|---|---|
| K– k+ | 90.9 |
| K+ k– | 0.4 |
| K+ k+ | 8.7 |
| Kp(a+b–) | <0.1 |
| Kp(a–b+) | 97.8 |
| Kp(a+b+) | 2.2 |
| Phenotype | % Frequency |
|---|---|
| Le(a+b–) | 22.4 |
| Le(a–b+) | 72.3 |
| Le(a–b–) | 5.3 |
| Phenotype | % Frequency |
|---|---|
| Fy(a+b–) | 19.7 |
| Fy(a–b+) | 32.7 |
| Fy(a+b+) | 47.6 |
| Fy(a–b–) | very rare |
| Phenotype | % Frequency |
|---|---|
| Jk(a+b–) | 26.3 |
| Jk(a–b+) | 23.6 |
| Jk(a+b+) | 50.1 |
| Jk(a–b–) | rare |
| Phenotype | % Frequency |
|---|---|
| Di(a+b–) | <0.01 |
| Di(a-b+) | >99.9 |
| Di(a+b+) | <0.1 |
| Wr(a+) | <0.01 |
| Wr(b+) | High incidence |
| Phenotype | % Frequency |
|---|---|
| Yt(a+b–) | 91.9 |
| Yt(a–b+) | 0.3 |
| Yt(a+b+) | 7.8 |
| Phenotype | % Frequency |
|---|---|
| Xg(a+) | Male-65.6 |
| Female-88.7 | |
| Xg(a–) | Male-34.4 |
| Female-11.3 |
| Phenotype | % Frequency |
|---|---|
| Sc:1,–2 | 99 |
| Sc:–1,2 | Rare |
| Sc:1,2 | 1 |
| Sc:1,–2,Rd+ | Rare |
| Sc:1,2,Rd+ | Rare |
| Phenotype | % Frequency |
|---|---|
| Do(a+b–) | 18 |
| Do(a–b+) | 33 |
| Do(a+b+) | 49 |
| Gy(a–) | Rare |
| Phenotype | % Frequency |
|---|---|
| Co(a+b–) | 90 |
| Co(a–b+) | 0.5 |
| Co(a+b+) | 9.5 |
| Phenotype | % Frequency |
|---|---|
| LW(a+b–) | 97 |
| LW(a–b+) | Rare |
| LW(a+b+) | 3 |
| Phenotype | % Frequency |
|---|---|
| Chido phenotype | |
| CH/RG: 1,2,3 | 88.2 |
| CH/RG: 1,–2,3 | 4.9 |
| CH/RG: 1,2,–3 | 3.1 |
| CH/RG: –1,–2,–3 | 3.8 |
| CH/RG: –1,2,-3 | Rare |
| CH/RG: 1,–2,–3 | Rare |
| Rodgers phenotype | |
| CH/RG: 11,12 | 95 |
| CH/RG: 11,–12 | 3 |
| CH/RG: –11,–12 | 2 |
| Phenotype | % Frequency |
|---|---|
| H | High incidence |
| Phenotype | % Frequency |
|---|---|
| Kx | High incidence |
| Phenotype | % Frequency |
|---|---|
| Ge:2,3,4 | >99.9 |
| Ge:–2,3,4 (Yus type) | Rare |
| Ge:–2,–3,4 (Gerbich type) | Rare |
| Ge:–2,–3,–4 (Leach) | Rare |
| Phenotype | % Frequency |
|---|---|
| Cra, Tca, Dra, Esa | High Incidence |
| Tcb, Tcc, WESa | Low incidence |
| Phenotype | % Frequency |
|---|---|
| Kn(a+b–) | 94.5 |
| Kn(a–b+) | 1 |
| Kn(a+b+) | 4.5 |
| McC(a+) | 98 |
| Sl(a+) | 98 |
| Yk(a+) | 92 |
| Phenotype | % Frequency |
|---|---|
| In(a+b–) | Rare |
| In(a–b+) | 99.9 |
| In(a+b+) | <0.1 |
| Phenotype | % Frequency |
|---|---|
| Ok(a+) | 100 |
| Ok(a–) | Rare |
| Phenotype | % Frequency |
|---|---|
| MER2 | 92 |
| Phenotype | % Frequency |
|---|---|
| JMH | High incidence |
| Phenotype | % Frequency |
|---|---|
| I | High incidence |
| Phenotype | % Frequency |
|---|---|
| P | High incidence |
| Phenotype | % Frequency |
|---|---|
| GIL | High incidence |
| Phenotype | % Frequency |
|---|---|
| Duclos | High incidence |
| Phenotype | % Frequency |
|---|---|
| FORS1 | Low incidence |
| Phenotype | % Frequency |
|---|---|
| Jra | High incidence |
| Phenotype | % Frequency |
|---|---|
| Lan | High incidence |
| Phenotype | % Frequency |
|---|---|
| Vel | High incidence |
| Phenotype | % Frequency |
|---|---|
| CD59.1 | High incidence |
| Phenotype | % Frequency |
|---|---|
| AUG1 | |
| AUG2 | >99% |
| Phenotype | % Frequency |
|---|---|
| Csa | 95 |
| Csb | 34 |
| Era | >99 |
| Erb | <1 |
| Er3 | >99 |
| Lec | 1 |
| Led | 6 |
| i | |
| LKE | 98 |
| Hu | |
| M1 | |
| Tm | |
| Can | |
| Sext | |
| Sj |
| Phenotype | % Frequency |
|---|---|
| By, Chra, Bi, Bxa, Pta, Rea, Jea , Lia, RASM, JFV, Kg, JONES, HJK, HOFM, REIT | <1 |
| Phenotype | % Frequency |
|---|---|
| Ata, AnWj, Sda | >90 |
| Emm, PEL, ABTI, MAM |
Note: Unless indicated, frequencies are based on blood group statistics of Australian blood donors; ** Frequency is based on Caucasian population.
References
- Daniels DL, Fletcher A, Garratty G, Henry S, Jorgensen J, Judd WJ et al. Blood group terminology from the International Society of Blood Transfusion committee on terminology for red cell surface antigens. Vox Sanguinis 2004;87:304–316.
- Garratty G, Dzik W, Issitt PD, Lublin DM, Reid ME, Zelinski T. Terminology for blood group antigens and genes - historical origins and guidelines in the new millennium. Transfusion 2004;40:477–489.
- Reid ME, Lomas-Francis C. Blood Group Antigens & Antibodies - A guide to clinical relevance and technical tips. SBB Books, New York, 2007.
- Seqirus. Antibody and antigen characteristics
- International Society of Blood Transfusion (ISBT). Red cell immonogenetics and blood group terminology. [cited 2016 Jun 27]. Available from: http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-blood-group-terminology/