Additives and anticoagulants

Anticoagulant for whole blood collections

CPD (citrate phosphate dextrose) 

Macopharma 

66.5 mL of CPD anticoagulant is used per pack of whole blood.

Constituents g/L Total per pack (g)
Sodium citrate dihydrate 26.3 1.75
Citric acid monohydrate 3.27 0.22
Monobasic sodium phosphate dihydrate 2.51 0.17
Dextrose monohydrate 25.5 1.70

 

Anticoagulant for plasmapheresis collections

4% sodium citrate 

Haemonetics Corporation 

250mL mixed ~ 1:16 with whole blood 

Constituents g/L
Sodium citrate dihydrate 40

 

Anticoagulant for plateletpheresis collections

ACD-A (acid citrate dextrose) 

Terumo BCT 

750mL mixed ~ 1:11 with whole blood 

Constituents g/L
Dextrose monhydrate 24.5
Sodium citrate dihydrate 22.0
Citric acid monohydrate 8.0

 

Red cell additive solution

SAGM (saline adenine glucose mannitol) 

Macopharma 

105 mL of SAGM is used as the additive solution for resuspension of standard red cell components. 

Constituents g/L Total per pack (g)
Sodium chloride 8.77 0.92
Adenine 0.169 0.02
Dextrose monohydrate 9.0 0.95
Mannitol 5.25 0.55

 

Washed red cells additive solution 

SAGM (saline adenine glucose mannitol) 

Macopharma 

250 mL of SAGM is for washing of red cells. 100 mL of SAGM is used as the additive solution for resuspension of washed red cells, red cells for IUT and thawed frozen red cells.  

Constituents g/L Total per pack (g)
Sodium chloride 8.77 0.877
Adenine 0.169 0.03
Dextrose monohydrate 8.18 0.818
Mannitol 5.25 0.525

 

Platelet additive solution (PAS) 

SSP+* 

Macopharma 

The volume of platelet additive solution contained in each unit of Platelets Pooled in SSP+ is approximately 70% of total component volume. 

The volume of platelet additive solution contained in each unit of Platelets Apheresis in PAS-E Leucocyte Depleted is approximately 60% of the total component volume. 

Constituents mg/100mL
Sodium chloride 405
Sodium acetate trihydrate 442
Sodium citrate dihydrate 318
Sodium dihydrogenophosphate 105
Di-sodium hydrogenophosphate 305
Potassium chloride 37
Magnesium chloride 30

*Note: PAS-E is the generic nomenclature adopted by ICCBBA to describe platelet additive solutions in terms of their active ingredients: citrate, phosphate, acetate, magnesium and potassium. This nomenclature allows for solutions with the same active ingredients from different commercial sources to be coded in the same manner. SSP+ is one of the PAS-E platelet additive solutions. 

Blood Component Information: An Extension of Blood Component Labels thumbnail

Blood Component Information: An Extension of Blood Component Labels

Guide
Information Sheet