Additives and anticoagulants

CPD (Citrate Phosphate Dextrose)

Macopharma

66.5 mL ± 10% of CPD anticoagulant is used per pack of whole blood.

Constituents g/L Total per pack (g)
Sodium citrate dihydrate 26.3 1.75
Citric acid monohydrate 3.27 0.22
Monobasic sodium phosphate dihydrate 2.51 0.17
Dextrose monohydrate 25.5 1.70

4% Sodium citrate

Haemonetics Corporation

250mL mixed ~ 1:16 with whole blood

Constituents g/L
Sodium citrate dihydrate 40

ACD-A (acid citrate dextrose)

Terumo BCT

750mL mixed ~ 1:11 with whole blood

Constituents g/L
Dextrose monhydrate 24.5
Sodium citrate dihydrate 22.0
Citric acid monohydrate 8.0

SAG-M (saline adenine glucose mannitol)

Macopharma

105 ± 10% mL of SAGM is used as the additive solution for resuspension of standard red cell components and washing of washed red cell components.

Constituents g/L Total per pack (g)
Sodium chloride 8.77 0.92
Adenine 0.169 0.02
Dextrose monohydrate 9.0 0.95
Mannitol 5.25 0.55

SAG-M2 (saline adenine glucose mannitol)

Macopharma

100 ± 10% mL of SAG-M2 is used as the additive solution for resuspension of washed red cell components.

Constituents g/L Total per pack (g)
Sodium chloride 8.77 0.877
Adenine 0.169 0.03
Dextrose monohydrate 8.18 0.818
Mannitol 5.25 0.525

SSP+*

Macopharma

The volume of platelet additive solution contained in each unit of Platelets Pooled in PAS-E Leucocyte Depleted is approximately 70% of total component volume.

The volume of platelet additive solution contained in each unit of Platelet Apheresis in PAS-E Leucocyte Depleted is approximately 60% of the total component volume.

Constituents mg/100mL
Sodium chloride 405
Sodium acetate trihydrate 442
Sodium citrate dihydrate 318
Sodium dihydrogenophosphate 105
Di-sodium hydrogenophosphate 305
Potassium chloride 37
Magnesium chloride 30

*Note: PAS-E is the generic nomenclature adopted by ICCBBA to describe platelet additive solutions in terms of their active ingredients: citrate, phosphate, acetate, magnesium and potassium. This nomenclature allows for solutions with the same active ingredients from different commercial sources to be coded in the same manner. SSP+ is one of the PAS-E Platelet Additive Solutions.