Use of cryodepleted plasma

This component contains most clotting factors in similar amounts to fresh frozen plasma; but is deficient in factor VIII, fibrinogen, von Willebrand factor, factor XIII and fibronectin.

It is recommended to use cryodepleted plasma for plasma exchange in patients with thrombotic thrombocytopenic purpura.

It can be an alternative to fresh frozen plasma for the treatment of coagulopathy where there is no significant reduction in factor VIII, fibrinogen, factor XIII or von Willebrand factor.

Examples include using cryodepleted plasma in rapid temporary warfarin reversal in patients requiring emergency surgery, and in warfarin overdose with life threatening bleeding in addition to Prothrombin Complex Concentrates. Vitamin K may be recommended for extended warfarin reversal.


Do not use cryodepleted plasma in the following situations:

  • when you can correct coagulopathy more effectively with specific therapy, such as vitamin K or specific factor concentrates

  • when you can safely and effectively replace blood volumes with volume expanders such as 0.9% Sodium Chloride Injection, Hartmann’s Solution, or appropriate colloids.


Volume depends on clinical situation, patient size and laboratory tests but the general guide is 10–15 mL/kg per dose.

For patients with specific factor deficiencies, always consider specific replacement therapy rather than cryodepleted plasma (eg. factor IX for haemophilia B)