Cryodepleted plasma

Asset 14a- Cryo-depleted Plasma_Apheresis_O Pos deep etched_0.jpgThis component is the supernatant remaining after cryoprecipitate has been removed from fresh frozen plasma, which is either derived from whole blood or collected via apheresis.

It contains most clotting factors in similar amounts to fresh frozen plasma but is deficient in Factor VIII, fibrinogen, von Willebrand Factor (the high molecular weight multimers are more thoroughly removed than the smaller multimers), Factor XIII and fibronectin.

Cryodepleted plasma can be stored for 12 months at –25˚ C or below.

Typical unit content and specifications

Information for WB-derived cryodepleted plasma (CDP) is based on the typical unit content from Blood Service data for the period 1 January to 31 December 2017 inclusive. The information for apheresis-derived CDP reflects the change in manufacturing process and is therefore based on limited validation data.

In both cases the mean (± 1 SD) and acceptable specification limits (in parentheses) are provided.

Volume (mL)
247 ± 13 (215265)
Volume (mL)
754 ± 3 (675–825)



Cryodepleted plasma derived from whole blood and apheresis is available in all ABO groups.


There is no modification available for cryodepleted plasma.


<< Previous page: Fresh frozen plasma  |  Next page: Cryoprecipitate >>