Washing of red cells removes unwanted plasma proteins, including antibodies. There will be some loss of red cells.
When should I use this modification?
This is given to patients who require red cells with a low protein supernatant.
The following groups of patients should receive washed components:
patients with reactions to transfused plasma proteins (eg, IgA deficiency)
patients with severe allergic reactions of unknown cause
patients with severe reactions despite leucocyte depletion
patients with paroxysmal nocturnal haemoglobinuria who experience reactions despite group-specific leucocyte depleted fresh red cells
- rarely, patients with T-activation when units from donors with low anti-T titres are not available or severe autoimmune haemolytic anaemia where excess complement may worsen destruction.