Fresh frozen plasma

07 LRI FFP.pngFresh frozen plasma (FFP) can be derived from either a donation of whole blood or apheresis plasma.

The freezing process must commence within 18 hours of collection for whole blood plasma and within 6 hours of collection for apheresis plasma.

FFP must be frozen to a core temperature below –30º C within 1 hour of commencement of the freezing process.

A unit of FFP contains all coagulation factors including the labile plasma coagulation Factors VIII and V. An adult dose contains approximately 200 IU of Factor VIII.

FFP has a shelf-life of 12 months when stored at –25º C or below.

Paediatric FFP is produced from a single adult unit of whole blood plasma which is then separated into four packs of equal volume. This reduces donor exposure for small paediatric transfusions and minimises product wastage.

Typical unit content and specifications

The typical unit content data is derived from Lifeblood process control testing. For each parameter, the mean value (± 1 SD) and specification is shown.

Unless otherwise specified data is for the period 1 January to 31 December 2018.

Volume (mL)
278 ± 13 (250–310)
Factor VIIIc (IU/mL)
1.09 ± 0.19 (> 0.70)
Volume (mL)
67 ± 4 (60–80)
Volume (mL)
271 ± 8 (250–310)
Factor VIIIc (IU/mL)
1.24 ± 0.15 (> 0.70)

 

Availability

This component is available in all ABO groups. Matching for RhD type is not necessary.

 

Modifications

Fresh frozen plasma can be modified as IgA deficient, low anti-T and secretor plasma Le(b+).
 

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